Obama will tape the interview on Wednesday in New York, co-host Kelly Ripa announced on Monday's show which airs on various local stations.
Her appearance will be the first lady's second time on the show this year. In June, she appeared on the show to promote her book American Grown: The Story of the White House Kitchen Garden and Gardens Across America. During that appearance, she also surprised a jump-roping team with a demonstration of her double-dutch jump-roping skills.
Republican candidate Mitt Romney and his wife, Ann, appeared on the show in September where they talked about reality TV star Snooki, his pet peeve of Ann's method of squeezing toothpaste out of the tube, and an embarrassing moment of walking in on former President George W. Bush receiving a massage during a White House visit.
Last week, Mrs. Romney co-hosted ABC's "Good Morning America" with George Stephanopolous where she made her family's traditional Welsh cakes and interviewed a thoroughbred horse rider from the Paralympics games in London in August.